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However, a dysregulated increase in the level of these free radicals, as seen in mitochondrial diseases, can result in oxidative damage by overwhelming the cellular antioxidant defence mechanism, of which glutathione is the principal component [4]

Reported skin whitening effect and antiaging and antimelanogenic effects likely stem from antioxidant activity and tyrosinase modulation

In contrast, activation of adenosine A 2A receptors tends to facilitate synaptic transmission, particularly in the hippocampus [343, 344]

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Most effective consumer topicals fall between 1 and 2%