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Older adults often have slower drug breakdown, which may raise the risk of side effects like nausea or vomiting
Semaglutide produced less weight loss than tirzepatide head-to-head, about 14% versus 20%. Its body-composition substudy measured a roughly 62:38 fat-to-lean loss split by mass, compared with about 75:25 for tirzepatide in a separate trial. The scan overstates muscle loss because lean mass includes water and organ tissue
Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a breakthrough therapy for obesity, overweight, and other associated health conditions, delivering unprecedented weight loss in clinical trials
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