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Patients were randomized to a 96-week course of metformin versus vitamin E versus placebo, and the primary outcome was ALT decrease, while histological improvement/NASH resolution was the secondary outcome

doi: 10.3389/fimmu.2019.02729 32 BalasundaramPFarhanaA

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The medication is not suitable for patients with a personal or family history of medullary thyroid carcinoma (MTC), MEN 2 syndrome (multiple endocrine neoplasia type 2 syndrome), or pancreatitis