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In terms of the individual MACE components, the present study informs clinicians that the impact of GLP-1RA, based on the NNT, is predominantly in the reduction of coronary revascularization risk, followed by total MI, then cardiovascular mortality, non-fatal MI and stroke
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10.2739/kurumemedj.50.1 8 ArakeriG.PatilS.MaddurN.Rao UsV.SubashA.PatilS.et al (2020)
Collectively, all GLP-1 receptor agonists, including native GLP-1, peptides, and small molecule GLP-1 receptor agonists, stabilize the binding pocket of the GLP-1 receptor in a similar fashion, which induces the TM helices 6 kink, a distinctive feature of the active state of the class B1 GPCR
