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The immunogenicity findings have important practical implications
Clinical data supporting fat loss in humans remains limited
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However, systemic effects from distant-site injection are also documented, and for diffuse neuropathies affecting multiple nerve territories, systemic administration may provide more uniform coverage
Optic Nerve Atrophy: Administering cyanocobalamin to patients with Leber's disease or hereditary optic nerve atrophy should be done cautiously, as it may worsen the condition
Most patients are injecting within days of their first visit
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