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Demonstrating efficacy in obesity-related comorbidities will be paramount in order to achieve reimbursement in Europe, yet it will take time for trials focused on these co-morbidities to translate into label expansion and revenues

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In addition, preclinical studies with dual-acting GIP/GLP-2 hybrid peptides demonstrate particular therapeutic promise for bone disorders, which merits further clinical exploration

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Similar trends were observed for systolic blood pressure, although the authors note that these analyses were exploratory and based on limited, inconsistently reported data

Vitamin E and glutathione are required for preservation of microsomal glutathione [PMID: 2371233] Laboratory literature summary: Vitamin E and glutathione are required for preservation of microsomal glutathione S-transferase from oxidative stress in microsomes