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In drug repositioning it is crucial to understand the disease-drug relationship, for this reason, there are several approaches to address the problem: In silico approaches: in this type of approach, various public databases, clinical trials, and bioinformatic systems are used to identify drug-target interactions ( Cluster approaches tend to find new drug-target or drug-disease relationships (Parisi et al., 2020)
mHTT impairs mitochondrial biogenesis, disrupts calcium handling, and promotes fission over fusion, leading to fragmented and inefficient mitochondria
10.1016/j.bbagen.2012.09.008 Biochim
Invest New Drugs 39 , 14841492 (2021)
It helps you burn fat better
What are the main benefits of berberine
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