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Several factors: cancer biology concerns with c-Met activation, replication uncertainty, lack of corporate funding for development, and the difficulty of cognitive enhancement drug development generally
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TPC2 controls pigmentation by regulating melanosome pH and size
Correspondingly, DKO* epidermis exhibits increased 4-hydroxynonenal (4-HNE) staining, a biomarker of lipid peroxidation, consistent with ferroptosis induction in this context
Rehman, S
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