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Average body weight dropped by 9.21 kg in the semaglutide group, while placebo patients showed minimal change

While some older GLP-1 agonists required daily dosing (such as liraglutide), the once-weekly formulations now dominate due to their ease of use and sustained effect

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A boxed warning is the most serious warning from the Food and Drug Administration (FDA) about drug effects that may be dangerous

however, DACRAs are known to directly suppress insulin secretion in an IVGTT, as well as directly on the pancreatic islets [1, 17], confirming weight independent effects