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The gradient starts with low density in the upper GI tract and it expands towards the rectum [32]

One study suggests that the decrease in vagal signaling seen with HFD feeding is due to upregulation of K+ channels in the nodose ganglia, increasing hyperpolarization of VANs 67 , while other studies have implicated changes in the gut microbiota as a contributor to vagal afferent desensitization during HFD feeding (see the Gut microbiotabrain connection section)

However, this type of pain can also radiate to other areas, including the side, back, or even the shoulder blade

Among these, the protease-activated receptor pathway serves as a central regulatory hub, primarily mediated by thrombin and aPC

PMID 10730193

& Croizier, S