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The substance is broadly safe in topical use at typical formulation concentrations of 0.05 to 0.2 percent

Jin L, Jin F, Guo S et al (2022) Metformin inhibits NLR family pyrin domain containing 3 (NLRP)-relevant neuroinflammation via an adenosine-5-monophosphate-activated protein kinase (AMPK)-dependent pathway to alleviate early brain injury after subarachnoid hemorrhage in mice

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Melatonin as a Potential Approach to Anxiety Treatment

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