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The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions
therefore, peptide dosing must be tailored to an individuals biochemistry 3
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The substitution at position 8, where alanine is replaced by 2-aminoisobutyric acid, is the protease-resistance change
According to statistics published by the Centers for Disease Control and Prevention (CDC), 94% of patients who died with COVID 19 in 2020 had an average of 2.9 lifestyle-related comorbidities
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