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Sublingual absorption of large peptides is inherently variable because it depends on factors like sublingual blood flow, saliva production, mucosal integrity, and even how much the user moves their tongue during the holding period
A.LadriereL.OrtisF.Igoillo-EsteveM.GurzovE
Semaglutide (weekly) is the most widely used
However, prolonged exposure to GLP-1RAs can lead to tachyphylaxis, reducing their effect on gastric emptying over time
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