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The drug suppresses appetite and drives weight loss through pharmacological mechanisms that reverse when the drug is discontinued
Normally, the excess of ROS in the mitochondria is neutralized by the endogenous antioxidant system which comprises several enzymes and non-enzymatic antioxidants [100] including reduced glutathione (GSH), vitamins C, and E, the Cu/Zn-superoxide dismutase (SOD) in the cytoplasm, and Mn-SOD in the mitochondrial matrix, catalase in the peroxisomes, glutathione peroxidase (GSH-Px), etc
Among several amino acids, L-glutamine is the most effective in promoting the release of GLP-1 via intracellular cAMP and Ca 2+ increases in GLUTag cells 38
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How the Combination Is Titrated in Practice When starting the combination, phentermine is typically introduced first to evaluate its effect on appetite control and ensure cardiovascular stability
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