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Type III and IV individuals see moderate darkening

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Nelson, Bryant, and Aks reported a case of systemic toxicity with rhabdomyolysis in Clinical Toxicology (Philadelphia) 2012: a 39-year-old male injected a supra-therapeutic milligram dose of internet-sourced MT-II subcutaneously and presented within two hours with diffuse muscle pain, tachycardia, mydriasis, hypertension, elevated creatinine, and creatine kinase that peaked in the five-figure international-units range by twelve hours [9]

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