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P21 drives neurogenesis to replace lost neurons

16-OHE 2 can be dehydrogenated to 16-hydroxyestrone (16-OHE 1 ), a metabolite that has been shown to bind covalently to the estrogen receptor via Schiff base formation

For the Sprague Dawley study, rats were single housed and had ad libitum access to a chow diet, kaolin pellets (K50001, Research Diets) and tap water

Both the GLP-1 injectable and oral forms mimic a natural hormone to regulate appetite, blood sugar and feeling full

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Competing interests Authors declare there is no conflict of interest