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Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes

This mechanism may partially counteract any tachyphylaxis that develops to exogenous GLP-1 receptor agonism over time by maintaining endogenous secretion of the hormone

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Light meals and spacing doses appropriately usually resolve this

Liraglutide has a longer overall safety track record, having been approved for weight management since 2015, compared with Wegovy, which was approved in 2022