Because the study was not powered to detect differences in secondary endpoints, no correction was used and these results should be interpreted with caution
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However, it is important to note that the reduction in CV deaths did not reach the prespecified threshold for statistical significance, meaning subsequent analyses should be viewed as hypothesis-generating rather than confirmatory
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Ischaemia induces mitochondrial alterations that predispose mitochondria to overproduce ROS during reperfusion
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