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Accessed at www.nejm.org/doi/full/10.1056/NEJMoa2206038

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Regarding prescribing: under the Human Medicines Regulations 2012 (regulation 167), doctors and some independent prescribers may prescribe unlicensed medicines (known as 'specials') when clinically necessary and when no licensed alternative is suitable, taking personal responsibility for that decision (GMC: Good practice in prescribing and managing medicines and devices)

placebo showed a statistically significant reduction in the sleep apnea index

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