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(Smith 2025) When weaning from anesthetic coma, the emergence of ictal-interictal continuum activity may be transient and doesnt necessarily require treatment intensification
This strategy suits users who plateau after several months suggesting diminishing returns, want to minimize long-term costs while maintaining some benefits, prefer avoiding indefinite commitments to any treatment, notice maintained improvements during initial breaks suggesting cycling viability, and value flexibility over maximum continuous optimization
JAMA, 2021
However, futile quinone redox cycling can lead to a cascade of ROS formation and as such, the link between toxicity and quinone redox cycling is widely acknowledged 5
In those scenarios the copper load is far less predictable, and there are no controlled human dosing studies establishing a safe threshold
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