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In addition, agonist binding increases NO-antiaggregating effects, cGMP/PKG/VASP pathway activation, reduces of PI3-K/Akt and MAPK/ERK-2 pathways activation, and decreases arachidonic acid (AA)-induced oxidative stress [93, 94] (Fig

alternative routes have unknown safety implications Efficacy : The dose-response relationship established in trials assumes subcutaneous delivery Tolerability : Gastrointestinal adverse effects (nausea, vomiting, diarrhea) are dose-dependent and may be affected by altered absorption Patients with lower body mass index or those injecting in areas with less subcutaneous fat may be at higher risk of inadvertent intramuscular injection if proper technique is not followed

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