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It does, however, intend to provide a practical overview of several (patho)physiological conditions in which knowledge of this interplay is important, to understand why and how metabolism responds

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Kadowaki, "Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats", Clinical and Experimental Nephrology

This reduction may compromise the liver's ability to manage oxidative stress and perform detoxification, potentially contributing to disease progression

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