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1999 Sep;16(9):1412-6

A randomized controlled trial of weight reduction as a treatment for breast cancer-related lymphedema

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206,220,221 Given that endoplasmic reticulum stress, impaired autophagy and proliferation, and increased apoptosis are all suggested to promote islet beta-cell pathology in T2D, and the findings that GLP-1R activation can influence all of these give GLP-1 and its analogues a role beyond just enhancing insulin secretion

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Liraglutide treatment also improved fatty liver in SKO mice, with reduced hepatomegaly, steatosis, markers of fibrosis and evidence of acute improvements of gluconeogenesis regulation in the PTT assays