Furthermore, exendin-4 has been found to stimulate -cell mass expansion and pancreas regeneration in a partial pancreatectomy rat model of T2DM (129)
Tirzepatide is an FDA-approved drug with completed Phase 3 obesity trials, while cagrilintide is investigational, with monotherapy data only through Phase 2 and its strongest results coming from the CagriSema combination
That is especially true with injectable options
Morsy, A
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Additionally, semaglutide's gastrointestinal effects, including nausea, vomiting, and diarrhea, are among the most commonly reported adverse reactions according to FDA prescribing information