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Metformin is a widely prescribed, first-line oral antidiabetic agent that acts primarily through activation of AMP-activated protein kinase (AMPK), a key regulator of glucose metabolism, insulin sensitivity, and inflammation 13,14

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Journal Of Cerebral Blood Flow And Metabolism , 41 , 761770

Especially, liraglutide as one the main GLP1-Ras by reducing mean BMI and body weight percentage affects improving WL outcomes