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Statements Author contributions YF: Conceptualization, Writing original draft

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Frequency: Follow the prescribed regimen which may start with frequent administrations (e.g., daily or weekly) before transitioning to a maintenance schedule (e.g., monthly)

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In silico examination of CBS promoter by Jaspar software 38 predicted one putative antioxidant response element (ARE) ~ 5 kb upstream of the transcription start site, which is highly associated with H3K4Me1, H3K4Me2, H3K4Me3, and H3K9Ac histone marks (Supplementary Fig

Maintenance use preserves results