A clinical insight in JAMA Internal Medicine makes the same point from the clinics perspective: diet and physical activity, it argues, remain crucial when prescribing GLP1s especially for protecting muscle, maintaining adequate nutrition, and turning shortterm weight loss into durable health gains
Data were selected for each complete year since the latest drug was marketed from 2018 quarter 1 to 2022 quarter 4
Semaglutide activates GLP-1 receptors to promote satiety and slower digestion, while tirzepatide targets both GLP-1 and GIP, which may lead to greater and sometimes faster weight loss
PubMed Maquart, F.X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J.C., & Borel, J.P
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Notably, the benefits appear to be more pronounced in patients with established ASCVD, reinforcing the importance of GLP-1 RAs as a cardioprotective intervention