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K., Massey, W
Immunocompromised patients, premature infants, critically ill individuals, those with central venous catheters, and patients with severe acute pancreatitis should avoid GLP-1 probiotics due to elevated risk of serious infections and adverse outcomes
Hormonal deficiencies (low estrogen, low testosterone, low growth hormone) and peptide protocols address overlapping but distinct biological systems
Another set of rats (n=5) in each group was applied to evaluate in vivo intestinal permeability
PMCID: PMC5397288.
Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025
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