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Hypoxic conditions can also lead to a phenomenon known as DPP-4 shedding whereby transmembrane DPP-4 is cleaved from the membrane and released into the circulation in a soluble form

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Nephron 1990;55(1):28-32

If participants made it past week 12 without discontinuing, they had an 87% chance of achieving at least 15% weight loss by week 48

This is different from the reported Cm effectors, which all have enzymatic activity 39,75,76

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