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A: The tortilla swap (flour to low-carb) saves the most calories (220 per tortilla)

This leads to effective, sustainable weight loss when combined with a healthy lifestyle

Patients should contact their GP, diabetes team or call NHS 111 if nausea significantly interferes with eating, drinking, or daily activities

Then the TRIUMPH-4 Phase 3 data arrived in late 2025 and exceeded expectations

Protocol adjustments If experiencing GI discomfort: Reduce to 0.5 mL weekly until tolerance improves If experiencing fishy body odor: This indicates excess trimethylamine production from choline/carnitine metabolism