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Receptor binding versus physiological effect Demonstrating that a molecule binds to GLP-1 and GIP receptors in vitro is a necessary but insufficient condition for therapeutic efficacy
Studies have suggested that GLP-1 receptor agonists might have neuroprotective effects
Combating TME-mediated resistance To counteract TME-driven resistance, a multipronged therapeutic approach is needed, one that combines tumor-intrinsic targeting with strategies that reprogram or neutralize the suppressive TME
Nature 494 , 185194 (2013) Mathi, S
Morris described how he followed a less conventional path through the study of medicine and how that and his early work experiences informed his decision to pursue clinical research in the diagnosis and treatment of prostate cancer
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