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Conclusion Despite an excellent design and a pristine execution, EVOKE and EVOKE+ offer a clear, albeit sobering, lesson: promising real-world correlations and mechanistic rationale do not automatically translate into disease-modifying effects in symptomatic Alzheimers disease

Patients are encouraged to seek medical advice promptly if they experience any unusual symptoms, and to consistently monitor their body weight compared to maximizing the benefits of this injectable prescription medicine

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FUNDING None NOTES None Acknowledgements Fig

Contraindications: Hypersensitivity to semaglutide or any of its excipients