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It has a favorable topical tolerability signal in cosmetics and preclinical models, but there is no published human trial quantifying its side effects, and no systemic/injectable safety data at all
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van Lookeren Campagne M, Thibodeaux H, van Bruggen N, Cairns B, Gerlai R, Palmer JT et al
Protocols in the 35% range, used once or twice daily over atrisk areas, are based on data showing that AHKCu can influence dermal papilla biology and growthfactor signaling in ways that might be protective
ammonia, -ketoglutarate or propionate), thus establishing a link between the trans-sulphuration pathway and the TCA cycle (as reviewed in Combs and DeNicola