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This is a significant clinical advantage, as it typically reduces the gastrointestinal side effects such as nausea and diarrhea often associated with immediate-release metformin, while allowing for convenient once-daily dosing

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Baseline estimated renal function was normal (eGFR 90 mL/min/1.73m 2 ) in 57.2%, mildly impaired (eGFR 60 to 90 mL/min/1.73m 2 ) in 35.9% and moderately impaired (eGFR 30 to 60 mL/min/1.73m 2 ) in 6.9% of patients

[2] By rapidly reversing the cyanosis and hypoxia of methemoglobinemia, MB improves oxygen delivery to tissues, often within minutes of administration

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Oxidative stress occurs when there is an imbalance between free radicals and antioxidants at the cellular level