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After the 15 th week of the study, four of the 24 patients in the glutathione group went on to develop neurotoxicity compared to 16 of 18 still reporting neurotoxicity in the placebo group
At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element
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