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however, research on how these molecules specifically impact the cardiac energy metabolism process is limited

Brown adipose tissue and BMP3b decrease injury in cardiac ischemia-reperfusion

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Both have similar biological effects that are caused by binding to the IGF-1 receptor (IGF-1R), whereas the IGF-2R is specific for IGF-2 and thought to have no physiological role except serving to degrade IGF-2 28 (Figure 1)

These may include issues related to intestinal permeability, irritation, or imbalance within the gut environment