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Kuhadiya ND, Mahmood I

Water-soluble -CCA accumulates preferentially in leaf tissues, where it activates drought- and -CC-responsive genes, including ATAF1 , RD29A , RD22 , RD26 , and bZip60 ( Arabidopsis , ATAF1, a NAC transcription factor, regulates drought adaptation through both ABA-dependent and ABA-independent pathways

It says some patients benefit from staying at 5 mg long term while others need escalation for continued progress, and it states that adjustments should occur only under provider guidance

doi: 10.1067/mcp.2002.121236 Horn J, Hansten P

Can do Vit -C, and Co Q10 (nondrowsy) or Benadryl (drowsy) instead

Dermatology 231 , 231238 (2015)