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In some cases, treatment may possibly include surgery, such as amputation

In addition, the aim of this analysis was to assess the impact of semaglutide on liver health in the overall population of patients in SELECT with overweight or obesity and established ASCVD

The databases used were PubMed, maintained by the US National Library of Medicine at the National Institutes of Health, Science Direct and Scopus by Elsevier, and Google Scholar (retrieved from 1 June to 26 August 2025)

And for others, it can help them taper off a GLP-1 while reducing their risk of rebound weight gain especially if they pair it with other lifestyle changes like regular physical activity and a nutritious diet

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These medications treat chronic conditionstype 2 diabetes and obesitythat typically need ongoing management