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Six enzymes of folic acid metabolism pathway were overexpressed, among which serine hydroxymethyltransferase 1 promoted the expression of cancer inflammatory factors by regulating sialic acid N-acetylneuraminic acid, and promoted the growth and metastasis of ovarian cancer tumor cells (69)
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Lokrantz and coworkers [72] recently reported the case of an old woman taking VPA monotherapy for her partial epilepsy in whom a typical hyperammonaemic encephalopathy was precipitated by treatment for a urinary tract infection with pivmecillinam an antibiotic known to decrease the serum concentration of carnitine