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Maes M, Leonard BE, Myint AM, Kubera M, Verkerk R (2011) The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
L-carnitine can be taken by mouth, as an intramuscular injection, and, in the form of acetyl-L-carnitine, intravenously
Because it interacts with more than one metabolic receptor, some individuals experience stronger appetite regulation or improved metabolic markers
The NICE guideline on obesity management (CG189) emphasises the importance of holistic care and monitoring of treatment-related effects, which includes attention to sleep quality as part of overall wellbeing assessment
In addition to common and mild side effects, it may cause some serious side effects in a few cases
1 Finally, GLP-1 has been linked to inhibiting gastrointestinal motility
