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Abstract The use of psychostimulants and alcohol disrupts blood-brain barrier (BBB) integrity, resulting in alterations to cellular function, and contributes to neurotoxicity

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Based on these experimental data, intraperitoneal injection led to observable behavioral improvements within 24 hours, while oral administration required several days of accumulation to reach a stable and significant effect

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549,550 This oxidative modification facilitates the recruitment of the von Hippel-Lindau protein (pVHL), which targets the oxidized HIF-1 for polyubiquitination and subsequent proteasomal degradation