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While endogenous IGF-1 is produced in the liver in response to growth hormone (GH), LR3 is engineered for enhanced performance with a half-life of 2030 hours compared to IGF-1s natural 2030 minutes

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Typical injection dosages can range from: 1,000 mcg (1 milligram) given weekly, monthly, or on a less frequent schedule depending on the severity of the deficiency and the individuals response

FDA Docket, various updates 2015 onward