The first formal Phase I human study of cyclic MT-II was reported by Dorr, Lines, Levine, Brooks, Xiang, Hruby, and Hadley in Life Sciences 1996 in three male research subjects at the University of Arizona [5]
Figtree GA, Vernon ST, Harmer JA, Gray MP, Arnott C, Bachour E, et al
Maintenance Dose: Once B12 levels are normalized, a maintenance dose of 1,000 mcg monthly or every few months may be recommended
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