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1 might be a possible treatment target for the clinical management of renal fibrosis

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Glutamine, through conversion to glutamate and subsequently to -ketoglutarate (-KG), not only fuels the tricarboxylic acid (TCA) cycle for energy generation but also contributes carbon skeletons for lipid, carbohydrate, and nucleotide biosynthesis, thus sustaining the high metabolic demands of activated fibroblasts [8]

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Amino acids are the building blocks of proteins