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One hypothesis is that Ozempics effect on slowing gastric emptying may overstimulate the gastrocolic reflex, which triggers the colon to move contents along the digestive tract more quickly, resulting in diarrhea
10.1016/j.bpa.2005.01.004 326
Usually these folks are not GSH allergic, but the pathways need to be clear first
Tirzepatide showed higher average weight loss in SURMOUNT trials, while semaglutide has a very large GLP-1 evidence base
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