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Methods to address confounding and other biases in meta-analyses: review and recommendations

p = 0.52 for interaction between subjects with established CVD vs risk factors only) (Fig

Important research boundary: These clinical trial results were achieved with FDA-approved branded medications studied under controlled conditions with specific manufacturing processes, quality controls, and dosing protocols

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It is important to recognize that the impact of AOMs will vary by age, reflecting differences in obesity levels, the mortality risk associated with obesity, and differences in uptake