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B vitamins decreased the number of M1 macrophages expressing the Ca1.2 channel and increased the number of M2 macrophages expressing the same channel, suggesting a role in M1/M2 transition post-PNI
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DUSP1, Dual Specificity Phosphatase 1
Moreover, microglia return to their resting morphology after systemic bacterial infection, even though the brain shows elevated proinflammatory mediators, including INF-, IL-1, and IL-12 (Puntener et al., 2012), suggesting microglial inflammatory responses are not fully resolved and remain in a primed state that can augment microglial responses in the context of subsequent stimuli
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