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10.4081/aiua.2023.10890 46 GonalvesC
In the brain, MAO-B converts it into a neurotoxin, MPP+, which can cause cell death in dopamine-producing neurons in the substantia nigra
Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-\(\kappa\)B activation and sensitizes toward TNF\(\alpha\)-induced cytotoxicity
10.3389/fphar.2021.794997 Front Pharmacol
The enhanced insulin response improves postprandial glucose control and reduces hemoglobin A1c levels by approximately 0.81.5% for GLP-1 receptor agonists, while the dual GIP/GLP-1 agonist tirzepatide often achieves greater reductions of 1.52.0% or more in clinical trials
