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[11] [12] For weight management, NICE (TA875, TA664) recommends these medications for adults with a BMI of 35 kg/m or more (or 32.5 kg/m or more for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds) who have at least one weight-related comorbidity and are receiving care through specialist weight management services
It still may trigger the side effects of GLP-1
Growth-factor enhancement of compromised gut function following massive small-bowel resection
It has been shown to increase blood flow, increase exercise tolerance, and relieve symptoms in those with peripheral artery disease
Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKC activation in diabetes
The "Uncoupling" Effect: Researchers have noted a physiological uncoupling where bone resorption (breakdown) increases, but bone formation (building) does not rise to compensate
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