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These cell lines have defects affecting the enzymes involved in the respiratory chain and are, therefore, unable to generate an electrochemical gradient across the mitochondrial membrane, concomitant with the loss of the glucose-induced increase of intracellular Ca 2+ [1113]

doi: 10.1016/S2213-2600(20)30161-2 219 PoeF

Presented for research literature review only Szilgyi M (1998)

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Barton, 2006